RNF2 Polyclonal Antibody
货号：PA5-40858
规格：100 µL
价格：4805
产品类型：标签抗体
品牌：Thermo Fisher
抗原：Synthetic peptide directed towards the middle regi
物种：人
宿主：兔
抗体亚型：IgG
荧光染料：其它
| 类型: | 一抗 | 同型对照： | |
| 浓度： | 1 mg/mL | 用法： | 5 µg/mL(IHC)；1-3 µg/mL（WB） |
产品详细信息Peptide sequence: LVFRPHPTLM EKDDSAQTRY IKTSGNATVD HLSKYLAVRL ALEELRSKGESequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100% 靶标信息RNF2 (E3 ubiquitin-protein ligase RING2) is a ligase that mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub). Therefore, it plays a central role in histone code and gene regulation. The ligase activity is enhanced by BMI1/PCGF4. H2AK119Ub gives a specific tag for epigeneti transcriptional repression and participates in X chromosome inactivation of female mammals. RNF2 may be involved in the initiation of both imprinted and random X inactivation. RNF2 is also an essential component of a Polycomb group (PcG) multiprotein PRC1-like complex. This complex class is required to maintain the transcriptionally repressive state of many genes including Hox genes throughout development. The PcG PRC1 complex acts via chromatin remodeling and modification of histones and rendering chromatin heritably changed in its expressibility.
| 数据： |
| RNF2 Antibody (PA5-40858) in IHCImmunohistochemistry analysis of human kidney tissue using an anti-RNF2 polyclonal antibody (Product # PA5-40858).RNF2 Antibody (PA5-40858) in WBWestern blot analysis of human HepG2 cell lysate using an anti-RNF2 polyclonal antibody (Product # PA5-40858). |
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