KMT2D Polyclonal Antibody

货号：PA5-49581

规格：400 µL

价格：4805

产品类型：标签抗体

品牌：Thermo Fisher

抗原：KLH conjugated synthetic peptide between 4980-5009

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	0.5 mg/mL	用法：	1:80,000(WB)

靶标信息KMT2D is a histone methyltransferase that methylates Lys-4 of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. KMT2D acts as a coactivator for estrogen receptors by being recruited by ESR1 and activating transcription. KMT2D is involved in chromatin organization, chormatin silencig, oocyte growth, oogenesis, and a positive regulation of cell proliferation. Mutations in the KMT2D gene cause Kabuki syndrome (KABUK1) which results in congential mental retardation syndrome.

数据：

KMT2D Antibody (PA5-49581) in WB Western blot analysis of MLL2 in recombinant protein whole cell lysate (20 µg). Samples were probed with a MLL2 Antibody (T4720) (Product # PA5-49581) at a 1:80000 dilution, followed by a Secondary Goat Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size : 593 kDa. Blocking/Dilution buffer: 5% NFDM/TBST. KMT2D Antibody (PA5-49581) in WB Western blot analysis of MLL2 using an MLL2 Antibody (T4720) (Product # PA5-49581) at 1:27000 dilution + HMML2 recombinant protein.

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