KMT2D Polyclonal Antibody

货号：PA5-57490

规格：100 µL

价格：5548

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Recombinant protein corresponding to Human KMT2D

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	0.3 mg/mL	用法：	0.25-2 µg/mL(ICC);0.25-2 µg/mL(IF)；1:200-1:500(IHC)

产品详细信息Immunogen sequence: AQLADTLFSK GLGPWDPPDN LAETQKPEQS SLVPGHLDQV NGQVVPEASQ LSIKQEPREE PCALGAQSVK REANGEPIGA PGTSNHLLLA GPRSEAGHLL LQKLLRAKNV QLSTGRGSEG LRAEINGHIHighest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 84%. 靶标信息KMT2D is a histone methyltransferase that methylates Lys-4 of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. KMT2D acts as a coactivator for estrogen receptors by being recruited by ESR1 and activating transcription. KMT2D is involved in chromatin organization, chormatin silencig, oocyte growth, oogenesis, and a positive regulation of cell proliferation. Mutations in the KMT2D gene cause Kabuki syndrome (KABUK1) which results in congential mental retardation syndrome.

数据：

KMT2D Antibody (PA5-57490) in IF Immunofluorescent staining of KMT2D in human cell line A-431 shows positivity in nucleus, plasma membrane and cytoplasm. Samples were probed using a KMT2D Polyclonal Antibody (Product # PA5-57490). KMT2D Antibody (PA5-57490) in IHC Immunohistochemical staining of KMT2D in human cervix, uterine using KMT2D Polyclonal Antibody (Product # PA5-57490) shows weak nuclear positivity in squamous epithelial cells.

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