Human 2B4/CD244 ELISA Kit/人2B4 / CD244 ELISA试剂盒
货号：EH3RB,EH3RBX5,EH3RBX10
规格：96 tests,5X96 tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 0.05 ng/mL |
| 检测范围 | 0.05-12 ng/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | CD244 |
| Protein aliases | CD244, CD244 molecule, natural killer cell receptor 2B4, h2B4, NAIL, Natural killer cell receptor 2B4, NK cell activation inducing ligand NAIL, NK cell activation-inducing ligand, NK cell type I receptor protein 2B4, NKR2B4, Signaling lymphocytic activation molecule 4, SLAM family member 4, SLAMF4 |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | 2B4, CD244, NAIL, NKR2B4, Nmrk, SLAMF4 |
| Gene ID | (Human) 51744 |
| Gene symbol | CD244 |
| UniProt ID | (Human) Q9BZW8 |
| Human 2B4/CD244 quantitates human 2B4/CD244 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human 2B4/CD244.人定量测定血清，血浆，上清液中的人2B4 / CD244。 该检测试剂盒将专门识别天然和重组人2B4 / CD244。Target information 靶标信息CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.CD244（2B4，SLAMF4）是在自然杀伤（NK）细胞（和某些T细胞）上表达的细胞表面受体，其介导非主要组织相容性复合物（MHC）限制性杀伤。 NK细胞和靶细胞之间通过CD244的相互作用被认为调节NK细胞的细胞溶解活性。 CD244与SLAMF2相互作用，导致SLAMF4和SLAMF2表达细胞均被激活。 系统性红斑狼疮患者的NK细胞和单核细胞表达的SLAMF4低于正常水平，这表明SLAMF4可能在这种自身免疫性疾病的病理中起作用。 与CD244功能障碍有关的疾病包括类风湿关节炎和淋巴增生综合征。 已经发现该基因的编码CD244的不同同工型的剪接的转录变体。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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