Human CD86/B7-2 ELISA Kit/人CD86 / B7-2 ELISA试剂盒
货号：EH99RB,EH99RBX5,EH99RBX10
规格：96 tests,5X96 tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 0.82 ng/mL |
| 检测范围 | 0.82-200 ng/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | CD86 |
| Protein aliases | Activation B7-2 antigen, B-lymphocyte activation antigen B7-2, B70, BU63, CD86, CD86 antigen (CD28 antigen ligand 2, B7-2 antigen), CTLA-4 counter-receptor B7.2, FUN-1, T-lymphocyte activation antigen CD86 |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | B7-2, B7.2, B70, CD28LG2, CD86, LAB72 |
| Gene ID | (Human) 942 |
| Gene symbol | CD86 |
| UniProt ID | (Human) P42081 |
| Human CD86/B7-2 quantitates human CD86/B7-2 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human CD86/B7-2.人CD86 / B7-2定量检测血清，血浆，上清液中的人CD86 / B7-2。该检测试剂盒将专门识别天然和重组人CD86 / B7-2。Target information 靶标信息CD86 is one of two ligands (the other CD80) for CTLA4 and CD28. CD86 acts as costimulatory molecule in eliciting T-cell help during antigen presentation. Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance. CD80 appears to play a role distinct from CD80 in T helper cell differentiation. CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. The CD86 protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms of CD86. Additional transcript variants have been described for CD86, but their full-length sequences have not been determined. Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.CD86是CTLA4和CD28的两个配体之一（另一个CD80）。 CD86在抗原呈递过程中作为共刺激分子在引发T细胞帮助中发挥作用。在没有涉及CD86 / CD80的足够共同刺激的情况下，抗原呈递可以诱导耐受性。 CD80在T辅助细胞分化中似乎起着不同于CD80的作用。 CD86是I型膜蛋白，是免疫球蛋白超家族的成员。 CD86蛋白由抗原呈递细胞表达，它是T细胞细胞表面上两种蛋白CD28抗原和细胞毒性T淋巴细胞相关蛋白4的配体。CD86与CD28抗原的结合是CD86抗原的共刺激信号。 T细胞的激活。 CD86与细胞毒性T淋巴细胞相关蛋白4的结合会负面调节T细胞活化并减少免疫反应。选择性剪接导致两个转录物变体编码CD86的不同同工型。已经描述了CD86的其他转录变体，但尚未确定其全长序列。与CD86功能障碍相关的疾病包括胆囊鳞状细胞癌和心肌炎。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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