Human 4-1BB Ligand ELISA Kit/人4-1BB配体ELISA试剂盒
货号：EH4RB,EH4RBX5,EH4RBX10
规格：96 tests,5X96 tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 0.2 ng/mL |
| 检测范围 | 0.2-50 ng/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | 4-1BBL (CD137L) |
| Protein aliases | 4-1BB ligand, 4-1BBL, homolog of mouse 4-1BB-L, receptor 4-1BB ligand, tumor necrosis factor (ligand) superfamily member 9, tumor necrosis factor (ligand) superfamily, member 9, tumor necrosis factor ligand 5A, Tumor necrosis factor ligand superfamily member 9 |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | 4-1BB-L, CD137L, TNFSF9, TNLG5A |
| Gene ID | (Human) 8744 |
| Gene symbol | TNFSF9 |
| UniProt ID | (Human) P41273 |
| Human 4-1BB Ligand quantitates human 4-1BB Ligand in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human 4-1BB Ligand.人4-1BB配体定量测定血清，血浆，上清液中的人4-1BB配体。该检测试剂盒将专门识别天然和重组人4-1BB配体。Target information 靶标信息CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.CD137配体（CD137L）是II型膜蛋白，是TNF超家族的一部分。 CD137L是一种共刺激分子，在抗原呈递细胞（DC，单核细胞/巨噬细胞，B细胞）上表达，并在激活后上调。它的受体CD137 / 4-1BB存在于多种细胞中，包括发炎的内皮细胞，其表达增强了表达CD137L的单核细胞的外渗。活化的T细胞还表达CD137，与CD137L的结合可增强T细胞增殖，IL-2分泌，存活和细胞毒性活性。 CD137L还可以在大多数B细胞淋巴瘤上表达，包括套细胞淋巴瘤，滤泡性淋巴瘤和弥漫性大B细胞淋巴瘤（但在霍奇金淋巴瘤和T细胞淋巴瘤上却缺乏）。 CD137L也在癌细胞系中表达，并被认为与T细胞-肿瘤细胞相互作用有关。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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