Rat Fas ELISA Kit/大鼠Fas ELISA试剂盒
货号：ERA15RB,ERA15RBX5
规格：96 Tests,5X96 Tests
价格：6641,29884
产品类型：ELISA检测
品牌：Thermo Fisher
物种：大鼠
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 40 pg/mL |
| 检测范围 | 40-10,000 pg/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | FAS (CD95) |
| Protein aliases | Apo-1 antigen, Apoptosis-mediating surface antigen FAS, CD95, CD95 antigen, Fas (TNF receptor superfamily, member 6), Fas antigen (ATP1), Fas receptor, FASLG receptor, Tumor necrosis factor receptor superfamily member 6, Tumor necrosis factor receptor superfamily, member 6 |
物种（Tested） | 大鼠 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | Apt1, Fas, Tnfrsf6 |
| Gene ID | (Rat) 246097 |
| Gene symbol | Fas |
| UniProt ID | (Rat) Q63199 |
| Rat Fas quantitates rat Fas in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat Fas.大鼠Fas定量分析血清，血浆和上清液中的大鼠Fas。该检测试剂盒将只识别天然和重组大鼠Fas。Target information 靶标信息FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. FAS also exists in a soluble form that weight approximately 26kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predominantly involved in anti-viral immune responses.FAS（Fas，CD95，APO-1）是一种46 kDa的跨膜糖蛋白，起TNFR（肿瘤坏死因子受体）超家族的细胞死亡受体的作用。 FAS还以重量约26kDa的可溶形式存在。刺激FAS导致其细胞内FAS相关死亡域（FADD）聚集，诱导死亡的信号传导复合物（DISC）形成和胱天蛋白酶激活。复合物中半胱氨酸蛋白酶的自动蛋白水解过程触发下游级联反应，导致细胞凋亡。 FAS已被证明可以激活NF-κB，MAPK3 / ERK1，MAPK8 / JNK，并参与正常二倍体成纤维细胞和T细胞中增殖信号的转导。已经描述了编码七个不同同工型的至少八个选择性剪接的转录变体。缺乏跨膜域的同工型可能负调控全长同工型介导的细胞凋亡。 Fas / Fas配体系统已显示出在许多人类疾病（如艾滋病，肝炎和癌症）中的作用。还假设通过FAS配体途径诱导细胞凋亡主要参与抗病毒免疫反应。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
©
Bio-Rad伯乐代理官网-伯乐抗体-伯乐层析Aminex色谱柱是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：
https://biorod.cn/thread-24865.htm
QQ:1749072012