| Rat IL-22 quantitates rat IL-22 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat IL-22.大鼠IL-22定量测定血清，血浆，上清液中的大鼠IL-22。该检测试剂盒将专门识别天然和重组大鼠IL-22。Target information 靶标信息IL-22 also known as IL-10-related T-cell derived inducible factor, is an alpha helical cytokine and is considered a member of the IFN-IL-10 family, which includes IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and the type I and II interferons. IL-22 is produced mainly by activated T cells and NK cells. In humans, the IL-22 gene is located on the q arm of chromosome 12, and is structurally related to IL10. IL-22 acts by engaging the heterodimeric receptor complex consisting of primary receptor IL-22R1 and accessory receptor IL-10R2. IL-22R1 also binds IL-20 and IL-24; IL-10R2 also binds IL-10, IL-27, IL-28, and IL-29. Binding of IL-22 to its receptor complex induces signal transduction, particularly via the JAK-STAT pathway. In addition to the membrane-bound IL-22R1/IL-10R2 complex, a soluble single-chain IL-22 receptor termed IL-22BP has been found to antagonize IL-22 binding and signaling. IL-22 appears not to directly influence immune cells, and major targets of the cytokine appear to be nonimmune cells, such as cells of the skin, digestive and respiratory system, as well as hepatocytes, and keratinocytes. IL-22 has been described as an effector cytokine of the Th17 lineage. Along with IL-17A and IL-17F, IL-22 regulates genes associated with innate immunity of the skin. IL-17A, IL-17F and IL-22 are all co-expressed by Th17 cells, however, they are differentially regulated. The effects of IL-22 include induction of acute phase reactants and antimicrobial proteins, as well as increasing the mobility of keratinocytes. IL-22 is highly expressed during chronic inflammation, and found to activate intracellular kinases and transcription factors. IL-22 is critical for host defense against infections of extracellular pathogens, and promotes wound-healing responses. IL-22 is upregulated in activated T cells. IL-22 has been reported to mediate IL-23-induced acanthosis and dermal inflammation through activation of STAT3.IL-22也称为IL-10-相关T细胞衍生诱导因子，是一种α螺旋细胞因子，被认为是IFN-IL-10家族的成员，其中包括IL-19，IL-20，IL-24 ，IL-26，IL-28，IL-29以及I型和II型干扰素。 IL-22主要由活化的T细胞和NK细胞产生。在人类中，IL-22基因位于12号染色体的q臂上，并且在结构上与IL10相关。 IL-22通过使由初级受体IL-22R1和辅助受体IL-10R2组成的异二聚体受体复合物起作用。 IL-22R1也结合IL-20和IL-24； IL-10R2还结合IL-10，IL-27，IL-28和IL-29。 IL-22与其受体复合物的结合诱导信号转导，特别是通过JAK-STAT途径。除了与膜结合的IL-22R1 / IL-10R2复合物外，还发现一种称为IL-22BP的可溶性单链IL-22受体可拮抗IL-22的结合和信号传导。 IL-22似乎不能直接影响免疫细胞，而细胞因子的主要靶点似乎是非免疫细胞，例如皮肤，消化系统和呼吸系统的细胞，以及肝细胞和角质形成细胞。 IL-22被描述为Th17谱系的效应细胞因子。 IL-22与IL-17A和IL-17F一起调节与皮肤先天免疫相关的基因。 IL-17A，IL-17F和IL-22均由Th17细胞共表达，但是它们受到差异调节。 IL-22的作用包括诱导急性期反应物和抗菌蛋白，以及增加角质形成细胞的活动性。 IL-22在慢性炎症中高表达，并能激活细胞内激酶和转录因子。 IL-22对于宿主防御细胞外病原体感染至关重要，并能促进伤口愈合反应。 IL-22在活化的T细胞中上调。据报道IL-22通过激活STAT3介导IL-23诱导的棘皮症和皮肤炎症。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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