Rat SCF ELISA Kit/大鼠SCF ELISA试剂盒
货号：ERA53RB,ERA53RBX5
规格：96 Tests,5X96 Tests
价格：6641,29884
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：大鼠
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 12 pg/mL |
| 检测范围 | 12-3,000 pg/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | SCF |
| Protein aliases | C-kit ligand, Hematopoietic growth factor KL, Kit ligand, Mast cell growth factor, MGF, SCF, sKITLG, Soluble KIT ligand, steel factor/kit ligand, Stem cell factor, stem cell factor KL-1 |
物种（Tested） | 大鼠 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | Kitl, Kitlg, Mgf, SCF |
| Gene ID | (Rat) 60427 |
| Gene symbol | Kitlg |
| UniProt ID | (Rat) P21581 |
| Rat SCF quantitates rat SCF in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat SCF.大鼠SCF定量测定血清，血浆，上清液中的大鼠SCF。 该检测试剂盒将专门识别天然和重组大鼠SCF。Target information 靶标信息Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.干细胞因子（SCF）是c-Kit癌基因的配体，由气道中的各种结构细胞和炎症细胞表达。 c-Kit受体与SCF的结合导致该受体的同二聚化，并激活诸如PI-3，PLC-γ，Jak / STAT和MAP激酶等信号通路。 SCF的表达导致肥大细胞存活的诱导以及组胺，促炎细胞因子和趋化因子的表达和释放。 SCF / c-Kit途径的抑制导致组胺水平降低，肥大细胞和嗜酸性粒细胞浸润，IL-4产生以及气道高反应性降低，表明该途径可能是炎性疾病（例如哮喘）的有用治疗靶标。 已知存在至少两个SCF同工型。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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