NO66 Polyclonal Antibody

货号：PA5-18655

规格：100 µg

价格：4880

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Synthetic peptide sequence (GAQHSDSKDPR) correspon

物种：人

宿主：山羊

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	0.5 mg/mL	用法：	0.3-1 µg/mL(WB)

产品详细信息This antibody is predicted to react with mouse and rat based on sequence homology.靶标信息Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. [UniProt]

数据：

NO66 Antibody (PA5-18655) in WBWestern Blot staining of A431 cell lysate usingProduct # PA5-18655at a concentration of 0.3 µg/mL, the primary antibody incubation was 1 hour and the detection method was chemiluminescence.

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