JMJD3 Polyclonal Antibody

货号：PA5-72751

规格：100 µg

价格：4880

产品类型：标签抗体

品牌：Thermo Fisher

抗原：JMJD3 antibody for a 16 amino acid synthetic pepti

物种：其它

宿主：兔

抗体亚型：IgG

荧光染料：其它

类型:	一抗	同型对照：
浓度：	1 mg/mL	用法：	2.5 µg/mL(ICC）；5 µg/mL(IF）；0.5 µg/mL(WB)

靶标信息Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.

数据：

JMJD3 Antibody (PA5-72751) in IFImmunocytochemistry analysis of JMJD3 in K562 cells. The samples were probed with a JMJD3 polyclonal antibody (Product # PA5-72751) at a dilution of 20 µg/mL. JMJD3 Antibody (PA5-72751) in ICCImmunocytochemistry analysis of JMJD3 in K562 cells. The samples were probed with a JMJD3 polyclonal antibody (Product # PA5-72751) with a dilution of 2.5 µg/mL. JMJD3 Antibody (PA5-72751) in WBWestern blot analysis of JMJD3 in HeLa cell lysate using JMJD3 polyclonal antibody (Product # PA5-72751) at a dilution of 0.25 µg/mL.

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