Canine SCF/KITLG ELISA Kit/犬SCF / KITLG ELISA试剂盒
货号：EC16RB,EC16RBX5,EC16RBX10
规格：96 Tests,5X96 Tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：其它
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 0.065 ng/mL |
| 检测范围 | 0.065-16 ng/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | SCF |
| Protein aliases | c-Kit ligand, Kit ligand, Mast cell growth factor, MGF, Processed kit ligand, SCF, sKITLG, Soluble KIT ligand, Stem cell factor, stem cell factor, CSF |
物种（Tested） | 狗 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | 710-712, CSF, KITLG, MGF |
| Gene ID | (Dog) 403507 |
| UniProt ID | (Dog) Q06220 |
| Gene symbol | KITLG |
| Canine SCF/KITLG quantitates canine SCF/KITLG in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant canine SCF/KITLG.犬SCF / KITLG定量检测血清，血浆，上清液中的犬SCF / KITLG。 该检测试剂盒将专门识别天然和重组犬SCF / KITLG。Target information 靶标信息Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.干细胞因子（SCF）是c-Kit癌基因的配体，由气道中的各种结构细胞和炎症细胞表达。 c-Kit受体与SCF的结合导致该受体的同二聚化，并激活诸如PI-3，PLC-γ，Jak / STAT和MAP激酶等信号通路。 SCF的表达导致肥大细胞存活的诱导以及组胺，促炎细胞因子和趋化因子的表达和释放。 SCF / c-Kit途径的抑制导致组胺水平降低，肥大细胞和嗜酸性粒细胞浸润，IL-4产生以及气道高反应性降低，表明该途径可能是炎性疾病（例如哮喘）的有用治疗靶标。 已知存在至少两个SCF同工型。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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