NO66 Polyclonal Antibody
货号：PA5-67597
规格：100 µL
价格：5956
产品类型：标签抗体
品牌：Thermo Fisher
抗原：Synthesized peptide derived from human NO66.
物种：人/小鼠/大鼠
宿主：兔
抗体亚型：IgG
荧光染料：其它
| 类型: | 一抗 | 同型对照： | |
| 浓度： | 1.1 mg/mL | 用法： | 1:45（IHC(P)） |
产品详细信息Predicted to react with Mouse and Rat samples.靶标信息Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation. May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation. [UniProt]
| 数据： |
NO66 Antibody (PA5-67597) in IHC (P)Immunohistochemical analysis of NO66 in paraffin-embedded Human lung cancer tissue using a NO66 Polyclonal Antibody (Product # PA5-67597) at a 1:45 dilution. (Original magnification: ×200). |
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