Feline IL-10 ELISA Kit/猫IL-10 ELISA试剂盒
货号：EF4RB,EF4RBX5,EF4RBX10
规格：96 Tests,5X96 Tests,10X96 tests
价格：6327,28472,54564
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：其它
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 0.2 ng/mL |
| 检测范围 | 0.2-50 ng/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | IL-10 |
| Protein aliases | CSIF, Cytokine synthesis inhibitory factor, IL-10, Interleukin-10 |
物种（Tested） | 猫 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | IL10 |
| Gene ID | (Cat) 493683 |
| Gene symbol | IL10 |
| UniProt ID | (Cat) P55029 |
| Feline IL-10 quantitates feline IL-10 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant feline IL-10.猫IL-10可定量测定血清，血浆，上清液中的猫IL-10。该检测试剂盒将只识别天然和重组猫IL-10。Target information 靶标信息Interleukin 10 (IL-10, CSIF) is an anti-inflammatory cytokine mainly produced by macrophages and Th2 cells. IL-10 is an 18.6 kDa protein of 160 amino acid residues that shares over 80% sequence homology with the Epstein-Barr Virus protein (BCRFI). The reported biological activities of IL-10, which maybe interrelated, include inhibition of macrophage-mediated cytokine synthesis, suppression of the delayed-type hyper-sensitivity response, and stimulation of the Th2 cell response which results in elevated antibody production. IL-10 functions by inhibiting pro-inflammatory cytokines made by macrophages and regulatory T cells including IFN-gamma, TNF-alpha, IL-2, and IL-3, IL-4, and GM-CSF. IL-10 is also known to suppress antigen presentation on antigen presenting cells, enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. While human IL-10 can act on murine cells, murine IL-10 cannot act on human cells. Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). IL-10 inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Knockout studies in mice suggest the function of this cytokine as an essential immunoregulator in the intestinal tract.白介素10（IL-10，CSIF）是一种主要由巨噬细胞和Th2细胞产生的抗炎细胞因子。 IL-10是一个160个氨基酸残基的18.6 kDa蛋白，与爱泼斯坦-巴尔病毒蛋白（BCRFI）具有80％以上的序列同源性。 IL-10的生物学活性可能相互关联，包括抑制巨噬细胞介导的细胞因子合成，抑制迟发型超敏反应以及刺激Th2细胞反应，从而导致抗体产生增加。 IL-10通过抑制巨噬细胞和调节性T细胞（包括IFN-γ，TNF-α，IL-2和IL-3，IL-4和GM-CSF）产生的促炎细胞因子发挥功能。还已知IL-10抑制抗原呈递细胞上的抗原呈递，提高B细胞存活，增殖和抗体产生。 IL-10可以阻断NF-κB的活性，并参与JAK-STAT信号通路的调节。虽然人IL-10可以作用于鼠细胞，但是鼠IL-10不能作用于人细胞。与细胞视黄醇结合蛋白II启动子（CRBPII-RXRE）的类视黄醇X受体（RXR）响应元件结合。 IL-10抑制视黄酸响应元件的9-顺式视黄酸依赖性RXRα转录激活。小鼠的基因敲除研究表明，这种细胞因子在肠道中是必需的免疫调节剂。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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