Mouse FAS/TNFRSF6/Apo-1 ELISA Kit/小鼠FAS / TNFRSF6 / Apo-1 ELISA试剂盒
货号：EM30RB,EM30RBX5,EM30RBX10
规格：96 Tests,5X96 Tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：小鼠
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 8.2 pg/mL |
| 检测范围 | 8.2-2,000 pg/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | FAS (CD95) |
| Protein aliases | Apo-1 antigen, Apoptosis-mediating surface antigen FAS, CD95, Fas (TNF receptor superfamily member), Fas antigen, FASLG receptor, lymphoproliferation, Tumor necrosis factor receptor superfamily member 6 |
物种（Tested） | 小鼠 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | AI196731, APO1, APT1, CD95, Fas, lpr, TNFR6, Tnfrsf6 |
| Gene ID | (Mouse) 14102 |
| Gene symbol | Fas |
| UniProt ID | (Mouse) P25446 |
| Mouse FAS/TNFRSF6/Apo-1 quantitates mouse FAS/TNFRSF6/Apo-1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse FAS/TNFRSF6/Apo-1.小鼠FAS / TNFRSF6 / Apo-1定量分析血清，血浆，上清液中的小鼠FAS / TNFRSF6 / Apo-1。该检测试剂盒将专门识别天然和重组小鼠FAS / TNFRSF6 / Apo-1。Target information 靶标信息FAS (Fas, CD95, APO-1) is a 46 kDa transmembrane glycoprotein that functions as a cell death receptor of the TNFR (tumor necrosis factor receptor) superfamily. FAS also exists in a soluble form that weight approximately 26kDa. Stimulation of FAS results in aggregation of its intracellular FAS-associated death domains (FADD), formation of the death-inducing signaling complex (DISC) and activation of caspases. The auto-proteolytic processing of the caspases in the complex trigger a downstream cascade that leads to apoptosis. FAS has been shown to activate NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. The Fas/Fas ligand system has been shown to play a role in a number of human diseases such as AIDS, hepatitis and cancer. It is also assumed that induction of apoptosis through FAS ligand pathway is predominantly involved in anti-viral immune responses.FAS（Fas，CD95，APO-1）是一种46 kDa的跨膜糖蛋白，起TNFR（肿瘤坏死因子受体）超家族的细胞死亡受体的作用。 FAS还以重量约26kDa的可溶形式存在。刺激FAS导致其细胞内FAS相关死亡域（FADD）聚集，诱导死亡的信号传导复合物（DISC）形成和胱天蛋白酶激活。复合物中半胱氨酸蛋白酶的自动蛋白水解过程触发下游级联反应，导致细胞凋亡。 FAS已被证明可以激活NF-κB，MAPK3 / ERK1，MAPK8 / JNK，并参与正常二倍体成纤维细胞和T细胞中增殖信号的转导。已经描述了编码八个不同同工型的至少八个选择性剪接的转录变体。缺乏跨膜结构域的同工型可能负调控由全长同工型介导的细胞凋亡。 Fas / Fas配体系统已显示出在许多人类疾病（如艾滋病，肝炎和癌症）中的作用。还假设通过FAS配体途径诱导细胞凋亡主要参与抗病毒免疫反应。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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