CBX4 Monoclonal Antibody (6C5G3)

货号：MA5-31666

规格：100 µL

价格：4806

产品类型：标签抗体

品牌：Thermo Fisher

抗原：Purified recombinant fragment of human CBX4 (AA: 3

物种：人

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：6C5G3

荧光染料：其它

类型:	一抗	同型对照：
浓度：	1 mg/mL	用法：	1:10,000（ELISA）；1:200-1:400（Flow）；1:200-1:1000(IHC(P));1:500-1:2000(WB）

靶标信息Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.

数据：

CBX4 Antibody (MA5-31666) in IHC (P)Immunohistochemistry analysis of CBX4 in paraffin-embedded cervical cancer tissue. Sample was incubated with CBX4 monoclonal antibody (Product # MA5-31666) using a dilution of 1:200-1:1000 followed by DAB staining. CBX4 Antibody (MA5-31666) in WBWestern blot analysis of CBX4 in HEK293 (1) and CBX4 cell lysate. Samples were incubated with CBX4 monoclonal antibody (Product # MA5-31666) using a dilution of 1:500-1:2000.

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