CD272 (BTLA) Monoclonal Antibody (MIH26), Functional Grade, eBioscience™/CD272 (BTLA) 单克隆 (MIH26), 功能抗体, eBioscience™
货号：16-5979-82
规格：100 µg
价格：3496
产品类型：流式抗体
品牌：eBioscience
抗原：CD272
物种：人
宿主：小鼠
抗体亚型：IgG2a, kappa
克隆号：MIH26
荧光染料：其它
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类型: | 一抗(功能抗体） | 同型对照： | Mouse IgG2a kappa Isotype Control (eBM2a), Functional Grade, eBioscience™ |
浓度： | 1 mg/mL | 用法： | 0.5 µg/test（Flow） |
产品详细信息Description: The BTLA monoclonal antibody reacts with human B and T lymphocyte attenuator (BTLA). BTLA is expressed by peripheral lymphocytes, splenic macrophages, developing B cells in the bone marrow and developing T cells in the thymus and mature, but not immature bone marrow-derived dendritic cells. BTLA is implicated as a negative regulator of the activation and/or function of various hemopoietic cell types. It is reported that BTLA binds to B7-H4, but further studies are needed to confirmthis interaction.Applications Reported: This MIH26 antibody has been reported for use in flow cytometric analysis.Applications Tested: This MIH26 antibody has been tested by flow cytometric analysis of normal human peripheral blood. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息BTLA or B and T-lymphocyte attenuator is a member of the co-inhibitory receptors of the CD28 superfamily. BTLA is a lymphocyte inhibitory receptor which inhibits lymphocytes during immunes responses. BTLA is constitutively expressed on most CD4+ and CD8+ T cells and its expression progressively decreases upon T cell activation. It remains expressed on Th1 cells, but not Th2 cells. BTLA is a unique co-receptor that interacts with the tumor necrosis factor receptor superfamily member herpesvirus entry mediator (HVEM). This interation is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.仅用于科研。不用于诊断过程。
数据 |
| CD272 (BTLA) Antibody (16-5979-82) in FlowStaining of normal human peripheral blood cells with 0.25 µg of Mouse IgG2a kappa Isotype Control Purified (Product # 14-4724-82) (open histogram) or 0.25 µg of Anti-Human CD272 (BTLA) Biotin (filled histogram) followed by Anti-Mouse IgG FITC (Product # 11-4011-85). Cells in the lymphocyte gate were used for analysis. |
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参考文献： |
| 流式1.Journal of immunology (Baltimore, Md. : 1950)T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment."16-5979 was used in Flow cytometry/Cell sorting to suggest that the HVEM-BTLA cis-complex competitively inhibits HVEM activation by ligands in the surrounding microenvironment, maintaining T cells in the naive state."AuthorsCheung TC,Oborne LM,Steinberg MW,Macauley MG,Fukuyama S,Sanjo H,D'Souza C,Norris PS,Pfeffer K,Murphy KM,Kronenberg M,Spear PG,Ware CF |
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