IL-13 Monoclonal Antibody (eBio13A), Functional Grade, eBioscience™/IL-13 单抗 (eBio13A), 功能抗体, eBioscience™

货号：16-7133-85,16-7133-38,16-7133-025,16-7133-050

规格：500 µg,5 mg,25 mg,50 mg

价格：3496,24089,72266,120443

产品类型：流式抗体

品牌：eBioscience

抗原：IL-13

物种：人/小鼠

宿主：大鼠

抗体亚型：IgG1, kappa

克隆号：eBio13A

荧光染料：Alexa Fluor 488

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类型:	一抗(功能抗体）	同型对照：	Rat IgG1 kappa Isotype Control (eBRG1), Functional Grade, eBioscience™
浓度：	1 mg/mL	用法：	1-4 µg/mL（ELISA）;Assay-Dependent（对照）;Assay-Dependent（功能检测）

产品详细信息Description: The eBio13A antibody reacts with mouse IL-13. IL-13 is a cytokine produced mainly by Th2 cells, but also by antigen-primed CD8 T cells. IL-13 has a strong involvement in allergic inflammation and parasitic clearing and in cancer models has been shown to have either inhibitory or stimulatory activity depending on the tumor. In humans, IL-13 is found to play a role in isotype switching in B cells. IL-13 is implicating in down modulating macrophage activity, through the reduction of pro-inflammatory cytokines (IL-1, IL-6, IL-8, IL-10, IL-12)Applications Reported: The eBio13A antibody has been reported useful for ELISA and ELISPOT capture, as well as intracellular staining for flow cytometric analysis.Applications Tested: The Functional Grade Purified eBio13A antibody has been tested by LAL assay to verify low endotoxin levels and has been tested for ELISA and ELISPOT capture.The eBio13A antibody has been tested as the capture antibody in a sandwich ELISA (and ELISPOT) for analysis of mouse IL-13, in combination with the biotinylated eBio1316H antibody for detection (13-7135) and recombinant mouse IL-13 (14-8131) as the standard. A suitable range of concentrations of this antibody for ELISA capture is 1.0 - 4.0 µg/mL. A standard curve consisting of doubling dilutions of the recombinant standard over the range of 1000 pg/mL - 8.0 pg/mL should be included in each ELISA plate.The Functional Grade Purified eBio1316H antibody (16-7135) is recommended for in vitro blocking studies.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF. The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.仅用于科研。不用于诊断过程。

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参考文献：

流式1.Arthritis research and therapyFli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells."Published figure using IL-13 monoclonal antibody (Product # 16-7133-85) in Flow Cytometry"2.ImmunityAutoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis."Published figure using IL-13 monoclonal antibody (Product # 16-7133-85) in Flow Cytometry"3.ImmunityE3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor."Published figure using IL-13 monoclonal antibody (Product # 16-7133-85) in Flow Cytometry"4.Arthritis research and therapyFli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells."Published figure using IL-13 monoclonal antibody (Product # 16-7133-85) in Flow Cytometry"中和5.Nature communicationsBacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages."Published figure using IL-13 monoclonal antibody (Product # 16-7133-85) in Neutralization"

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