IL-13 Monoclonal Antibody (PVM13-1), Functional Grade, eBioscience™/IL-13 单克隆 (PVM13-1), 功能抗体, eBioscience™

货号：16-7139-81

规格：50 µg

价格：1156

产品类型：流式抗体

品牌：eBioscience

抗原：IL-13

物种：人

宿主：小鼠

抗体亚型：其它

克隆号：PVM13-1

荧光染料：其它

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类型:	一抗(功能抗体）	同型对照：	IgG1
浓度：	1 mg/mL	用法：	Assay-Dependent（ELISA）;Assay-Dependent（中和）;Assay-Dependent（功能检测）

产品详细信息Description: The PVM13-1 antibody reacts with human interleukin-13 (IL-13). IL-13, also known as NC30, is a 12.5 kDa protein secreted by activated T helper cells, CD8^+ T cells, and NK cells. The biological activities of IL-13 include suppression of macrophage cytotoxic activity, upregulation of IL-1RA expression and suppression of inflammatory cytokine expression.Applications Reported: The PVM13-1 antibody has been reported for use as the capture antibody in an IL-13 ELISPOT assay or ELISA, as well as for neutralization of IL-13 bioactivity.Applications Tested: The functional grade PVM13-1 antibody has been tested for ELISA and ELISPOT capture and neutralization of IL-13 bioactivity. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Storage and handling: Use in a sterile environment.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and is involved in regulating inflammatory and immune responses. IL-13 down-regulates macrophage activity, thereby inhibiting the production of pro-inflammatory cytokines and chemokines, and is involved in allergen-induced asthma through mechanisms independent of IgE and eosinophils. IL-13 also regulates several stages of B cell maturation and differentiation, up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. Structurally, IL-13 closely resembles IL-3, IL-4, IL-5 and GM-CSF. The gene encoding IL-13, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with the IL-13 gene particularly close to IL4.仅用于科研。不用于诊断过程。

数据

IL-13 Antibody (16-7139-81) in ELISANormal human peripheral blood cells (300,000/well) in 100 µl complete RPMI medium were treated without (left) or with (right) Candida (100 µg/mL) for 24 hrs in an IL-13 ELISPOT assay.

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