CD85k (Gp49b) Monoclonal Antibody (H1.1), Functional Grade, eBioscience™/CD85k (Gp49b) 单克隆 (H1.1), 功能抗体, eBioscience™
货号：16-5784-85,16-5784-38,16-5784-025,16-5784-050
规格：500 µg,5 mg,25 mg,50 mg
价格：3496,24089,72266,120443
产品类型：流式抗体
品牌：eBioscience
抗原：CD85k
物种：小鼠
宿主：Armenian hamster仓鼠
抗体亚型：IgG
克隆号：H1.1
荧光染料：其它
_ueditor_page_break_tag_
类型: | 一抗(功能抗体） | 同型对照： | Armenian Hamster IgG Isotype Control (eBio299Arm), Functional Grade, eBioscience™ |
浓度： | 1 mg/mL | 用法： | Assay-Dependent（功能检测）；Assay-Dependent（中和） |
产品详细信息Description: The monoclonal antibody H1.1 recognizes gp49, a receptor with structural similarities to the PIR (paired Ig-activating receptors) and ILT/KIR(killer inhibitory receptors) family of proteins. Two closely linked genes on mouse chromosome 10 encode the related proteins gp49A and gp49B. These two receptors are almost 90% identical in their extracellular regions but differ in their cytoplasmic domains; gp49B contains an ITAM domain while gp49A does not and is extremely short. Expressionof gp49 was originally identified on mast and LAK (IL-2 activated NK) cells. Expression on LAK cells has been shown to be predominantly gp49B with only a small amount of gp49A. Additionally gp49 is found on myeloid cells. Detailed function is not known but gp49B can inhibit cellular activation. The monoclonal antibody H1.1 recognizes both gp49A and gp49B. The H1.1 antibody has been shown to have functional activity: when crosslinked along with anti-NK1.1 it can prevent cytokine release in KY-2 cells.Applications Reported: The H1.1 antibody has been reported for use in flow cytometric analysis and functional assays. It has been reported to block cytokine release.Applications Tested: This H1.1 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2 µm post-manufacturing filtered.Purity: Greater than 90%, as determined by SDS-PAGE.Endotoxin Level: Less than 0.001 ng/µg antibody, as determined by LAL assay.Aggregation: Less than 10%, as determined by HPLC.靶标信息This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].仅用于科研。不用于诊断过程。
©
Bio-Rad伯乐代理官网-伯乐抗体-伯乐层析Aminex色谱柱是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：
https://biorod.cn/thread-26476.htm
QQ:1749072012