CD4 Monoclonal Antibody (SK3 (SK-3)), Alexa Fluor 700
货号：56-0047-41,56-0047-42
规格：25 Tests,100 Tests
价格：881,2039
产品类型：流式抗体
品牌：Thermo Fisher
物种：人
宿主：小鼠
抗体亚型：IgG1, kappa
荧光染料：Alexa Fluor 700
| 抗体类型 | 单抗 | 同型对照： | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Alexa Fluor 700 |
| 浓度： | 5 µL/Test | 用法： | 5 μL (0.25 μg)/test (Flow) |
| 产品详细信息Description: The SK3 monoclonal antibody reacts with human CD4, a 59-kDa cell surface receptor expressed by a majority of thymocytes, a subpopulation of mature T helper cells, and at low levels on monocytes. CD4 is a receptor for the human immunodeficiency virus (HIV). SK3 blocks HIV binding and mixed lymphocyte reaction. The SK3 and RPA-T4 monoclonal antibodies do not cross-block binding, suggesting recognition of distinct epitopes.Applications Reported: This SK3 antibody has been reported for use in flow cytometric analysis.Applications Tested: This SK3 antibody has been pre-diluted and tested by flow cytometric analysis of normal human peripheral blood cells. This may be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Alexa Fluor® 700 emits at 723 nm and can be excited with the red laser (633 nm). Most instruments will require a 685 LP mirror and 710/20 filter. Please make sure that your instrument is capable of detecting this fluorochrome.Excitation: 633-647 nm; Emission: 723 nm; Laser: Red Laser靶标信息The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017]. |
| 数据 |
| CD4 Antibody (56-0047-41) in FlowNormal human peripheral blood cells were stained with CD3 Monoclonal Antibody, FITC (Product # 11-0038-80) and Mouse IgG1 kappa Isotype Control, Super Bright 780 (Product # 78-4714-82) (left) or CD4 Monoclonal Antibody, Super Bright 780 (right). Cells in the lymphocyte gate were used for analysis. |
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| 参考文献： |
| 1.mSystemsMultiple Sclerosis-Associated Changes in the Composition and Immune Functions of Spore-Forming Bacteria."56-0047 was used in Flow cytometry/Cell sorting to identify multiple sclerosis-associated spore-forming taxa and show that their presence correlates with impaired differentiation of IL-10-secreting, regulatory T lymphocytes in vitro."AuthorsCekanaviciute E,Pröbstel AK,Thomann A,Runia TF,Casaccia P,Katz Sand I,Crabtree E,Singh S,Morrissey J,Barba P,Gomez R,Knight R,Mazmanian S,Graves J,Cree BAC,Zamvil SS,Baranzini SE |
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