CD45RO Monoclonal Antibody (UCHL1), APC

货号：17-0457-41,17-0457-42

规格：25 T,100 T

价格：1112,3035

产品类型：流式抗体

品牌：eBioscience

抗原：CD45RO

物种：人

宿主：小鼠

抗体亚型：IgG2a, kappa

克隆号：UCHL1

荧光染料：APC

类型:	单抗	同型对照：	Mouse IgG2a kappa Isotype Control (eBM2a), APC
浓度：	5 µL/Test	用法：	5 µL (0.03 µg)/test(Flow)

产品详细信息Description: The UCHL1 monoclonal antibody reacts with human CD45RO, a 180 kDa isoform of CD45. CD45RO is expressed by most thymocytes, activated memory T cells, granulocytes and monocytes. CD22 is a ligand for CD45RO. Expression of CD45RO and CD45RA is used commonly to discriminate subsets of peripheral T cells.Applications Reported: This UCHL1 antibody has been reported for use in flow cytometric analysis.Applications Tested: This UCHL1 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.03 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD45RO (UCHL1, ubiquitin carboxyl terminal esterase L1) is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RO is expressed on macrophages, CD8+ T cells, activated T cells and myeloma cells. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.

数据

CD45RO Antibody (17-0457-41) in FlowStaining of normal human peripheral blood cells with Anti-Human CD45RA PE (Product # 12-0458-42) and Mouse IgG2a kappa Isotype Control APC (Product # 17-4724-81) (left) or Anti-Human CD45RO APC (right). Cells in the lymphocyte gate were used for analysis.

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参考文献

1. PloS oneHuman Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor eomesodermin.2. Cell researchBlocking the recruitment of naive CD4+T cells reverses immunosuppression in breast cancer.3. Journal of immunology (Baltimore, Md. : 1950)Fc receptor-like 3 protein expressed on IL-2 nonresponsive subset of human regulatory T cells.4. PloS oneGalectin-9 activates and expands human T-helper 1 cells.5. BMC immunologyDifferential expression of CD300a/c on human TH1 and TH17 cells.

技术参数

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