Rat IgM Isotype Control (eBRM), eFluor 660
货号：50-4341-80,50-4341-82
规格：25 ug,100 ug
价格：954,1806
产品类型：大鼠同型对照
品牌：eBioscience
物种：其它
宿主：大鼠
抗体亚型：IgM
克隆号：eBRM
荧光染料：eFluor 660
| 类型: | 同型对照 | 同型对照： | |
| 浓度： | 0.2 mg/mL | 用法： | Assay-Dependent(Flow)；Assay-Dependent(Ctrl) |
产品详细信息Description: The monoclonal rat IgM K is useful as an isotype control immunoglobulin.Applications Reported: Rat IgM Isotype Control eFluor® 660 has been reported for use in flow cytometric analysis.Applications Tested: Rat IgM Isotype Control has been tested by flow cytometric analysis of normal human peripheral blood cells and mouse spleen cells. It should be used at the same concentration as the experimental antibody.eFluor® 660 is a replacement for Alexa Fluor® 647. eFluor® 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome.Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息Immunoglobulin M is the third most common serum Ig and can exist as pentamer where all heavy chains are identical and all light chains are identical or as a monomer (e.g. found on B lymphocytes as B - cell receptors). The large pentameric structure allows for building of bridges between encountered epitopes on molecules that are too distant as to be connected by smaller IgG antibodies. IgM is built as the first antibody during an immune response and is responsible for agglutination and cytolyticreactions since its pentameric structure gives it 10 free antigen binding sites in theory and it posseses a high avidity. Due to conformational constraints among the 10 Fab portions, IgM only has a valence of 5. Additionally, IgM is not as versatile as IgG, but it is of vital importance in complement activation and agglutination. IgM is predominantly found in the lymph fluid and the blood and is a very effective neutralizing agent in the early stages of disease. Elevated levels can be a sign of recent infection or exposure to antigen.
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