CD5 Monoclonal Antibody (53-7.3), Biotin, eBioscience™

货号：13-0051-82,13-0051-85

规格：100μg,500μg

价格：1029,2580

产品类型：流式抗体

品牌：eBioscience

抗原：CD5

物种：小鼠

宿主：大鼠

抗体亚型：IgG2a, kappa

克隆号：53-7.3

荧光染料：Biotin

抗体类型:	小鼠流式抗体	同型对照：	Rat IgG2a kappa Isotype Control (eBR2a), Biotin, eBioscience
浓度：	0.5mg/mL	用法：	0.125 µg/test (Flow)

Description:The 53-7.3 monoclonal antibody reacts with mouse CD5, a 67 kDa protein expressed by a majority of thymocytes, mature T cells and a subset of B cells. The expression of CD5 by a small subset of B cells characterizes a developmentally and functionally distinct lineage of B cells called B-1 cells. CD5 is a counter-receptor for CD72 and plays a role in the T-B cell interaction.Applications Reported: The 53-7.3 antibody has been reported for use in flow cytometric analysis.<br>Applications Tested: The 53-7.3 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.125 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2 µm post-manufacturing filtered.Target InformationCD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

数据：

CD5 Antibody (13-0051-82) in FlowStaining of mouse splenocytes with Anti-Mouse CD5 FITC (left), and PE (right). Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.

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参考文献：

1.The Journal of experimental medicineDistinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory."13-0051 was used in Flow cytometry/Cell sorting to reveal distinct cellular pathways that select germline-encoded and somatically mutated antibodies into immunological memory."2.eLifeDifferential requirement of kindlin-3 for T cell progenitor homing to the non-vascularized and vascularized thymus."Published figure using CD5 monoclonal antibody (Product # 13-0051-82) in Flow Cytometry"3.Journal of virologyHost Tumor Suppressor p18INK4cFunctions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis."Published figure using CD5 monoclonal antibody (Product # 13-0051-82) in Flow Cytometry"

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