CD137 (4-1BB) Monoclonal Antibody (17B5), APC,
货号：17-1371-80,17-1371-82
规格：25 ug ,100 ug
价格：1038,2630
产品类型：流式抗体
品牌：eBioscience
抗原：CD137 (4-1BB)
物种：小鼠
宿主：其它
抗体亚型：IgG
克隆号：17B5
荧光染料：APC
| 类型: | 单抗 | 同型对照： | Syrian Hamster IgG Isotype Control, APC |
| 浓度： | 0.2 mg/mL | 用法： | 0.25 µg/test(Flow) |
产品详细信息Description: The 17B5 monoclonal antibody reacts with mouse CD137, also known as 4-1BB, a member of the TNFR superfamily. CD137 is expressed as monomers, dimers, and tetramers on the surface of activated T cells around day 4-6 after activation through the TCR complex. Interaction of CD137 with its ligand, 4-1BBL, is reported to deliver a costimulatory signal important in the T-APC interaction. Recent data suggests CD317 is expressed on Tregs and may play a role in their proliferation. The monoclonal antibody 17B5 has strong antagonistic effect in in vitro functional assays.Applications Reported: This 17B5 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 17B5 antibody has been tested by flow cytometric analysis of stimulated mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
| 数据 |
CD137 (4-1BB) Antibody (17-1371-80) in FlowStaining of unstimulated (left) or 3-day PHA-stimulated (right) BALB/c splenocytes with Anti-Mouse CD278 (ICOS) FITC (Product # 11-9942-82) and 0.125 µg of Anti-Mouse CD137 (4-1BB) APC (right). Total viable cells were used for analysis. |
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| 参考文献 |
| 1. Cancer immunology researchVaccination with High-Affinity Epitopes Impairs Antitumor Efficacy by Increasing PD-1 Expression on CD8+T Cells.2. Cell reportsPulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.3. Journal of immunology (Baltimore, Md. : 1950)The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells. |
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