CD137 (4-1BB) Monoclonal Antibody (17B5), Biotin,
货号:13-1371-82
规格:100 µg
价格:1148
产品类型:流式抗体
品牌:eBioscience
抗原:CD137 (4-1BB)
物种:小鼠
宿主:Syrian hamster
抗体亚型:IgG
克隆号:17B5
荧光染料:Biotin
类型: | 单抗 | 同型对照: | Syrian Hamster IgG Isotype Control, Biotin |
浓度: | 0.5 mg/mL | 用法: | 0.5 µg/test(Flow) |
产品详细信息Description: The 17B5 monoclonal antibody reacts with mouse CD137, also known as 4-1BB, a member of the TNFR superfamily. CD137 is expressed as monomers, dimers, and tetramers on the surface of activated T cells around day 4-6 after activation through the TCR complex. Interaction of CD137 with its ligand, 4-1BBL, is reported to deliver a costimulatory signal important in the T-APC interaction. Recent data suggests CD317 is expressed on Tregs and may play a role in their proliferation. The monoclonal antibody 17B5 has strong antagonistic effect in in vitro functional assays.Applications Reported: The 17B5 antibody has been reported for use in flow cytometric analysis.Applications Tested: The 17B5 antibody has been tested by flow cytometric analysis of activated mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
数据 |
CD137 (4-1BB) Antibody (13-1371-82) in FlowStaining of ConA-stimulated mouse splenocytes with Anti-Mouse CD137 (4-1BB) PE. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis. |
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参考文献 |
1. Journal of immunology (Baltimore, Md. : 1950)4-1BB ligand signaling to T cells limits T cell activation.2. Cell reportsPulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer.3. Cancer immunology, immunotherapy : CIIConcomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma.4. Cancer immunology, immunotherapy : CIIConcomitant targeting of programmed death-1 (PD-1) and CD137 improves the efficacy of radiotherapy in a mouse model of human BRAFV600-mutant melanoma.5. Journal of immunology (Baltimore, Md. : 1950)The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells. |
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