CD137 Ligand (4-1BB Ligand) Monoclonal Antibody (TKS-1), Biotin,

货号：13-5901-82

规格：100 µg

价格：1545

产品类型：流式抗体

品牌：eBioscience

抗原：CD137 Ligand

物种：小鼠

宿主：其它

抗体亚型：IgG

克隆号：4-1BB Ligand

荧光染料：Biotin

类型:	单抗	同型对照：	Rat IgG2a kappa Isotype Control (eBR2a), Biotin,
浓度：	0.5 mg/mL	用法：	1 µg/test(Flow)

产品详细信息Description: The TKS-1 monoclonal antibody reacts with mouse 4-1BB Ligand (4-1BBL), a type II transmembrane protein and a member of the tumor necrosis factor superfamily. 4-1BBL is expressed by activated antigen presenting cells including B cells and macrophages. Interaction of 4-1BBL with 4-1BB (CDw137) is reported to deliver a costimulatory signal important in the T-APC interaction.Applications Reported: The TKS-1 antibody has been reported for use in flow cytometric analysis.Applications Tested: The TKS-1 antibody has been tested by flow cytometric analysis of resting and 2-3 day (IgM & CD40)-activated mouse splenocytes. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.

数据

CD137 Ligand (4-1BB Ligand) Antibody (13-5901-82) in FlowStaining of mouse splenocytes unstimulated (left) or Anti-Mouse IgM plus Anti-Mouse CD40 Functional Grade Purified (Product # 16-0402-82stimulated splenocytes (right) with Anti-Mouse 4-1BB Ligand PE. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.

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参考文献

1. Journal of immunology (Baltimore, Md. : 1950)4-1BB ligand signaling to T cells limits T cell activation.2. Journal of immunology (Baltimore, Md. : 1950)The 4-1BB costimulation augments the proliferation of CD4+CD25+ regulatory T cells.3. European journal of microbiology & immunologyImpact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.

技术参数

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