CD278 (ICOS) Monoclonal Antibody (7E.17G9), FITC
货号：11-9942-80,11-9942-82
规格：25μg,100μg
价格：943,1897
产品类型：流式抗体
品牌：Thermo Fisher
物种：小鼠
宿主：大鼠
抗体亚型：IgG2b, kappa
荧光染料：FITC
| 抗体类型 | 一抗 | 同型对照： | Rat IgG2b kappa Isotype Control (eB149/10H5), FITC |
| 浓度： | 0.5 mg/mL | 用法： | |
| 产品详细信息Description: The 7E.17G9 monoclonal antibody reacts with mouse ICOS (Inducible COStimulatory molecule), a T cell specific molecule and a third member of the CD28/CTLA-4 family. A homodimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1 and is thought to play a protective role in inflammatory autoimmune diseases. ICOS may be involved in the development of Th2 cells.Applications Reported: This 7E.17G9 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 7E.17G9 antibody has been tested by flow cytometric analysis of Con A-stimulated mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD278 belongs to the CD28 and CTLA-4 cell-surface receptor family and is highly expressed in activated T-cells. It is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. It enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. |
| 数据 |
| CD278 (ICOS) Antibody (11-9942-80) in FlowStaining of unstimulated (left) and 3-day Con A-stimulated (right) BALB/c splenocytes with 0.06 µg of Rat IgG2b K Isotype Control FITC (Product # 11-4031-82) (blue histogram) or 0.06 µg of Anti-Mouse CD278 (ICOS) FITC (purple histogram). Total viable cells, as determined by Fixable Viability Dye eFluor® 660, were used for analysis. |
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| 参考文献： |
| 1.Nature immunologyRapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis."11-9942 was used in Flow cytometry/Cell sorting to investigate the role of the brain in innate immunological signals, showing rapid linkage of innate signals and adaptive immunity by the brain-fat axis."2.Journal of immunology (Baltimore, Md. : 1950)IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells."11-9942 was used in Flow cytometry/Cell sorting to investigate the role of germinal centres in autoimmunity, showing that IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells."3.Nature communicationsRoquin targets mRNAs in a 3'-UTR-specific manner by different modes of regulation."Published figure using CD278 (ICOS) monoclonal antibody (Product # 11-9942-82) in Flow Cytometry"4.Experimental and therapeutic medicineEffect of follicular helper T cells on the pathogenesis of asthma."11-9942 was used in Flow cytometry/Cell sorting to investigate the effect of follicular helper T cells on bronchial asthma."5.Nature immunologyRapid linkage of innate immunological signals to adaptive immunity by the brain-fat axis."11-9942 was used in Flow cytometry/Cell sorting to investigate the role of the brain in innate immunological signals, showing rapid linkage of innate signals and adaptive immunity by the brain-fat axis." |
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