| 产品介绍 | | |
| Rabbit anti Human MFN2 antibodyrecognizes MFN2, also known as hyperplasia suppressor, mitochondrial assembly regulatory factor or transmembrane GTPase MFN2.The MFN2 gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in MFN2 gene cause Charcot-Marie-Tooth disease type 2A2 (CMT2A2), and hereditary motor and sensory neuropathy VI (HMSN6A), which are both disorders of the peripheral nervous system. Defects in MFN2 have also been associated with early-onset stroke (Chunget al.2008). Two transcript variants encoding the same protein have been identified. (provided by RefSeq, Jul 2008).Rabbit anti Human MFN2 antibody detects a band of 80 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG - liquid |
| Preparation | Rabbit polyclonal antibody purified by affinity chromatography. |
| Buffer Solution | Phosphate buffered saline. |
| Preservative Stabilisers | 0.09% Sodium Azide (NaN3). |
| Immunogen | KLH conjugated synthetic peptide corresponding to amino acid 447-476 of human MFN2 |
| Acknowledgements | PrecisionAb is a trademark of Bio-Rad Laboratories. |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Store undiluted at -20°C, avoiding repeated freeze thaw cycles |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Western Blotting | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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