Rabbit anti Human KDELR1 antibody
货号：VPA00390
规格：100 µl
价格：2890
产品类型：免疫组化一抗
品牌：Bio-Rad
物种：人
宿主：兔
抗体亚型：IgG
荧光染料：Purified
| 产品介绍 | | |
| Rabbit anti Human KDELR1 antibodyrecognizes KDELR1, also known as ER lumen protein retention receptor 1 and putative MAPK-activating protein PM23.Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetra-peptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor is encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by the KDELR1 gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product (provided by RefSeq, Jul 2008).Rabbit anti Human KDELR1 antibody detects a band of 28 kDa. The antibody has been extensively validated for western blotting using whole cell lysates. |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG - liquid |
| Preparation | Rabbit polyclonal antibody purified by affinity chromatography. |
| Buffer Solution | Phosphate buffered saline. |
| Preservative Stabilisers | 0.09% Sodium Azide (NaN3). |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa 185-211 of human KDELR1 |
| Acknowledgements | PrecisionAb is a trademark of Bio-Rad Laboratories. |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Store undiluted at -20°C, avoiding repeated freeze thaw cycles |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Western Blotting | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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