| 产品介绍 | | |
| Goat anti Human TDP-43 antibodyrecognizes human TAR DNA-binding protein 43, also known as TDP-43, the product of the TAR DNA-binding protein 43 gene. TDP-43 is a 414 amino acid DNA and RNA binding protein containing 2RRMdomains involved in regulation of transcription and splicing. TDP-43 is ubiquitously expressed with high levels being seen in pancreas, gall bladder, alimentary tract, reproductive system, adipose tissue, skin and skeletal muscle.Mutations in the TPD43 gene are implicated in development of Amyotrophic lateral sclerosis 10, a neurodegenerative disorder affecting motor neurons leading to eventual fatal paralysis (Van Deerlinet al.2008).Goat anti Human TDP-43 antibody recognizes human TDP-43 as a single band of ~45kDa in multiple cell line lysates by western blotting under reducing conditions. The antibody also cross-reacts with rodent cell line lysates tested. |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG - liquid |
| Preparation | Goat polyclonal antibody purified by ammonium sulfate precipitation followed by antigen affinity chromatography. |
| Buffer Solution | TRIS buffered saline. |
| Preservative Stabilisers | 0.02% Sodium Azide (NaN3)0.5% Bovine Serum Albumin |
| Immunogen | Peptide sequence C-HISNAEPKHNSNRQ from an internal region of TDP-43. |
| Acknowledgements | PrecisionAb is a trademark of Bio-Rad Laboratories. |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Store undiluted at -20°C, avoiding repeated freeze thaw cycles |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Western Blotting | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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