Mouse anti Human interleukin-11, clone C01-1C2
货号：MCA5964GA
规格：0.1 mg
价格：2576
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原：interleukin-11
物种：人
宿主：小鼠
抗体亚型：IgG1
克隆号：C01-1C2
荧光染料：Purified
| 产品介绍 | | |
| Mouse anti Human interleukin-11, clone C01-1C2,recognizes human interleukin-11 (IL-11), a 178 amino acid non-glycosylated pleiotropic cytokine, also known as AGIF. IL-11 is a 19 kDa member of the IL-6 of cytokines. It signals through a high affinity receptor complex, made up of the IL-11 receptor alpha chain (IL-11Ralpha) and gp130 which triggers homo- or hetero-dimerization of gp130. Although gp130 and its dimer partners possess no kinase activity, the dimerization of gp130 leads to activation of tyrosine kinases and modulation of transcriptional activity.IL-11 is an important regulator in the haematopoiesis of erythroid, myeloid and megakaryocyte progenitor cells and is expressed in a variety of tissues including the lung, bone, thymus and connective tissue. Expression of IL-11 in endometrial stromal cells is vital for normal murine embryo development, and implicated in decidualization during human pregnancy. IL-11 is a functionally diverse signalling molecule with roles in megakaryopoiesis (Dams-Kozlowskaet al.2013), bone growth (Simset al.2005) and T cell proliferation (Curtiet al.2002). |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein G from ascites |
| Buffer Solution | Phosphate buffered saline |
| Immunogen | E. coliderived recombinant protein corresponding to aa 23-125 of human IL-11 |
| Fusion Partners | Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2/0 myeloma cell line |
| Preservative Stabilisers | 0.1% Sodium Azide (NaN3)0.1% Bovine Serum Albumin |
| Approx. Protein Concentrations | IgG concentration 1.0 mg/ml |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| ELISA | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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| 文献 |
| 1.Curti, A.et al.(2002) Interleukin-11 induces proliferation of human T-cells and its activity is associated with downregulation of p27(kip1)Haematologica 87: 373-80.2.Dams-kozlowska, H.et al.(2013) Designer cytokine hyper interleukin 11 (H11) is a megakaryopoietic factor.Int J Med Sci. 10 (9): 1157-65.3.Sims, N.A.et al.(2005) Interleukin-11 receptor signaling is required for normal bone remodelingJournal of Bone and Mineral Research 20: 1093–102. |
技术参数 产品应用 Elisa
产品类型 Monoclonal Antibody
推荐用于 Elisa
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