Rat anti Mouse CD36 antibody, clone MF3
货号：MCA2748PE
规格：100 Tests
价格：3553
产品类型：流式抗体
品牌：Bio-Rad
抗原：CD36
物种：小鼠
宿主：大鼠
抗体亚型：IgG2a
克隆号：MF3
荧光染料：PE
| 产品介绍 | | |
| Rat anti Mouse CD36 antibody, clone MF3recognizes mouse CD36, also known as platelet glycoprotein 4, glycoprotein IIIb or PAS IV. CD36 is an ~85 kDa multipass transmembrane glycoprotein primarily expressed on platelets, monocytes/macrophages, smooth muscle and endothelial cells. The CD36 molecule is type B scavenger receptor, which binds to multiple ligands including thrombospondin, anionic phospholipids, oxidized low density lipoproteins and long chain fatty acids.CD36 has diverse functions and is reported to play a role in innate immunity, platelet adhesion/aggregation and long chain fatty acid transport. The CD36 molecule also directly mediates cytoadhesion of erythrocytes infected withPlasmodium falciparum, and may be involved in the development of atherosclerotic lesions and the formation of foam cells.Rat anti Mouse CD36 antibody, clone MF3 has been shown to inhibit IL-4 induced thioglycollate-elicited peritoneal macrophage fusion and significantly block IL-4/GM-CSF-induced bone-marrorw derived macrophage fusion. |
| 产品详情 | | |
| Target Species | Mouse |
| Product Form | Purified IgG conjugated to R. Phycoerythrin (RPE) - lyophilized |
| Preparation | Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
| Buffer Solution | Phosphate buffered saline |
| Fusion Partners | Spleen cells from immunised DA rats were fused with cells of the Y3Ag 1.2.3 myeloma cell line |
| Preservative Stabilisers | 0.09% Sodium Azide (NaN3)1%Bovine Serum Albumin |
| Approx. Protein Concentrations | IgG concentration 0.05 mg/ml |
| Max Ex/Em | Fluorophore | Excitation Max (nm) | Emission Max (nm) |
| RPE 488nm laser | 496 | 578 |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Store at +4℃. DO NOT FREEZE.This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Flow Cytometry | √ | Neat | 1/10 |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
| 同型对照 |
| Description | Product Code | Applications | Pack Size |
| Rat IgG2a Negative Control:RPE | MCA1212PE | F | 100 Tests/1ml |
| 文献 |
| 1.Helming, L.et al.(2009) The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion.J Cell Sci. 122 (Pt 4): 453-9.2.Mwaikambo, B.R.et al.(2009) Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms.J Biol Chem. 284: 26695-707.3.Yang, C.N.et al.(2011) Mechanism mediating oligomeric Aβ clearance by naïve primary microglia.Neurobiol Dis. 42 (3): 221-30.4.Seeds, R.E.et al.(2011) The role of myeloid receptors on murine plasmacytoid dendritic cells in induction of type I interferon.Int Immunopharmacol. 11: 794-801.5.Samovski, D.et al.(2012) Insulin and AMPK regulate FA translocase/CD36 plasma membrane recruitment in cardiomyocytes via Rab GAP AS160 and Rab8a Rab GTPase.J Lipid Res. 53 (4): 709-17. |
技术参数 产品应用 Flow
产品类型 Monoclonal Antibody
推荐用于 Flow
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