mouse anti human CLUSTERIN
货号：MCA2612
规格：0.1 mg
价格：4616
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原：Clusterin
物种：人
宿主：小鼠
抗体亚型：IgG1
克隆号：3R3/2
荧光染料：Purified
| 产品介绍 | | |
| Mouse anti Human clusterin antibody, clone 3R3/2recognizes clusterin, an ubiquitously expressed protein of two 40 kDa chains, alpha and beta, covalently joined by disulfide bonds. It exists in two forms; a pro-apoptotic form localised to the nucleus and a pro-survival secreted form. Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX, Clusterin suppression can sensitise cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas.Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimer's disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells. |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified Ig - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein A from ascites |
| Buffer Solution | Borate buffered saline |
| Immunogen | Glomerular basement membrane from a post-mortem kidney. |
| Approx. Protein Concentrations | IgG concentration 1.0 mg/ml |
| Preservative Stabilisers | 0.1% Sodium Azide (NaN3) |
| Regulatory | For research purposes only |
| Guarantee | Guaranteed until date of expiry. Please see product label. |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| ELISA | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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| Goat anti Mouse IgG:HRP (Rat Adsorbed) | STAR77 | C;E;P | 0.5mg |
| 文献 |
| 1.Kumita, J.R.et al.(2007) The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.J Mol Biol. 369 (1): 157-67.2.Shannan, B.et al.(2006) Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control.J Mol Histol. 37 (5-7): 183-8. |
技术参数 产品应用 Flow;IHC(F);WB;ELISA
产品类型 单克隆抗体
推荐用于 Flow;IHC(F);WB;ELISA
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