mouse anti human SC5b-9
货号：MCA2611
规格：0.1 mg
价格：4616
产品类型：流式抗体
品牌：Bio-Rad
抗原：SC5b-9
物种：人
宿主：小鼠
抗体亚型：IgG2a
克隆号：056B-75.2.3.10 (3R2/0)
荧光染料：Purified
| 产品介绍 | | |
| Mouse anti Human SC5b-9 antibody, clone 056B-75.2.3.10 (3R2/0)recognizes the SC5b-9 complex of around 330 kDa. Both the classical and alternative complement pathways result in the formation of the cytolysis inducing C5b-9 complex. This complex is composed of 190 kDa C5b which is bound to cells via 71 kDa C9. Sublytic assembly of C5b-9 on plasma membranes induces cell cycle activation and survival. The binding of C5b-9 to the 75 kDa S-protein (or vitronectin) in the fluid phase prevents C5b-9 from assembling on the plasma membrane, deactivating it and forming the SC5b-9 complex. SC5b-9 is stable in vitro and is therefore a reliable indicator of terminal complement pathway activation.Removal of Sodium Azide is recommended prior to use in functional assays.Mouse anti Human SC5b-9 antibody, clone 3R2/0 has been reported to work in western blotting applications. |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified Ig - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein A from ascites |
| Buffer Solution | Borate buffered saline |
| Immunogen | Purified human C5. |
| Approx. Protein Concentrations | Current, batch-specific concentration 1.176 mg/ml |
| Preservative Stabilisers | 0.1% Sodium Azide (NaN3) |
| Regulatory | For research purposes only |
| Guarantee | Guaranteed until date of expiry. Please see product label. |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| ELISA | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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| 文献 |
| 1.Biesecker, G. (1990) The complement SC5b-9 complex mediates cell adhesion through a vitronectin receptor.J Immunol. 145 (1): 209-14.2.Greenstein, J.D.et al.(1995) The kinetics and distribution of C9 and SC5b-9in vivo: effects of complement activation.Clin Exp Immunol. 100 (1): 40-6.3.Rus, H.et al.(2005) C5b-9 complement complex in autoimmune demyelination and multiple sclerosis: dual role in neuroinflammation and neuroprotection.Ann Med. 37 (2): 97-104. |
技术参数 产品应用 Flow;IHC(F);WB;ELISA
产品类型 单克隆抗体
推荐用于 Flow;IHC(F);WB;ELISA
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