mouse anti human C3c
货号：MCA2605
规格：0.1 mg
价格：5925
产品类型：流式抗体
品牌：Bio-Rad
抗原：C3c
物种：人
宿主：小鼠
抗体亚型：IgG1
克隆号：013E-498.2.3 (10-02A)
荧光染料：Purified
| 产品介绍 | | |
| Mouse anti human C3c, clone 013E-498.2.3 (10-02A),recognizes the ~135 kDa complement component 3c present in serum. C3c is generated over the course of complement activation, where convertase C4b2a (classical pathway) and convertase C3bBb (alternative pathway) cleave C3 to C3b and C3a. C3b is further degraded into iC3b and C3dg/C3d. iC3b is then slowly cleaved (possibly by factor I) to form C3c (beta chain + alpha' chain fragment 1 + alpha' chain fragment 2), C3dg and C3f.C3 is crucial in the induction of tolerance generated when an antigen is introduced into immunoprivileged sites and this is exploited by pathogens and cancer cells to evade the immune system by inhibiting complement activation. |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein A from ascites |
| Buffer Solution | Borate buffered saline |
| Immunogen | Human C3 from normal serum, highly purified by chromatography. |
| Approx. Protein Concentrations | Current, batch-specific concentration 1.2 mg/ml |
| Preservative Stabilisers | 0.1% Sodium Azide (NaN3) |
| Regulatory | For research purposes only |
| Guarantee | Guaranteed until date of expiry. Please see product label. |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Flow Cytometry | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
| 推荐产品 |
| Description | Product Code | Applications | Pack Size |
| Mouse IgG1 Negative Control | MCA928 | F | 100 Tests/1ml |
| 文献 |
| 1.Sica, M.et al.(2017) Eculizumab treatment: stochastic occurrence of C3 binding to individual PNH erythrocytes.J Hematol Oncol. 10 (1): 126. |
技术参数 产品应用 Flow;IHC(F);WB;ELISA
产品类型 单克隆抗体
推荐用于 Flow;IHC(F);WB;ELISA
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