Rat anti mouse CD80
货号：MCA2462,MCA2462GA,MCA2462T
规格：0.25 mg,0.1 mg,25 µg
价格：3018,2015,808
产品类型：流式抗体
品牌：Bio-Rad
抗原：CD80
物种：小鼠
宿主：大鼠
抗体亚型：IgG2a
克隆号：RM80
荧光染料：Purified
| 产品介绍 | | |
| Rat anti Mouse CD80 antibody, clone RM80recognizes mouse CD80 (B7-1), a ~60 kDa cell surface glycoprotein which is a member of the CD28/B7 family. In mice, CD80 is expressed on monocytes, peritoneal macrophages and dendritic cells, and expression may be significantly increased upon B lymphocytes by LPS and by IL-4.CD80 has been identified as a ligand for CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA-4), two structurally similar molecules expressed on T cells. CD28 and CTLA4 are two receptors that have essential but opposing functions in T-cell stimulation. The Interaction of CD80 with CD28 stimulates and sustains T cell responses, whereas the interaction of CD80 with CTLA4 is reported to inhibit T-cell responses. |
| 产品详情 | | |
| Target Species | Mouse |
| Product Form | Purified IgG - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
| Fusion Partners | Spleen cells from immunised SD rats were fused with cells of the P3U1 myeloma cell line. |
| Buffer Solution | Phosphate buffered saline |
| Immunogen | BCL1 cells expressing CD80. |
| Approx. Protein Concentrations | IgG concentration 1.0mg/ml |
| Preservative Stabilisers | 0.09%Sodium Azide1%Bovine Serum Albumin |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Store at +4℃. DO NOT FREEZE.This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Flow Cytometry | √ | 1/10 | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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| 文献 |
| 1.Nuriya, S.et al.(1996) The differential role of CD86 and CD80 co-stimulatory molecules in the induction and the effector phases of contact hypersensitivity.Int Immunol. 8 (6): 917-26.2.Jin LPet al.(2004) Adoptive transfer of paternal antigen-hyporesponsive T cells induces maternal tolerance to the allogeneic fetus in abortion-prone matings.J Immunol. 173 (6): 3612-9.3.Nakajima, A.et al.(1997) Requirement of CD28-CD86 co-stimulation in the interaction between antigen-primed T helper type 2 and B cells.Int Immunol. 9 (5): 637-44.4.Nozawa, K.et al.(2001) Preferential blockade of CD8(+) T cell responses by administration of anti-CD137 ligand monoclonal antibody results in differential effect on development of murine acute and chronic graft-versus-host diseases.J Immunol. 167 (9): 4981-6. |
技术参数 产品应用 :IHC(F) ;Flow Cytometry;
产品类型 单克隆抗体
推荐用于 :IHC(F) ;Flow Cytometry;
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