Mouse anti Sheep CD230 (PrPSc)
货号：MCA2460
规格：0.25 mg
价格：3162
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原：CD230
物种：绵羊
宿主：小鼠
抗体亚型：IgG2a
克隆号：2G11
荧光染料：Purified
| 产品介绍 | | |
| Mouse anti Sheep CD230 (aa151 - aa159) antibody, clone 2G11recognizes CD230 and can be used to detect the plaques which are formed during the progression of prion disease. Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal infectious neurodegenerative diseases of humans and animals. These diseases are biologically unique, as they are believed by some to be transmitted by an infectious agent comprised only of protein, with no nucleic acid component. Clinically, these diseases present with motor disturbances and behavioural changes. The major pathological changes seen are neuronal loss, vacuolation (spongiform change), proliferation and branching of glial cells, astrocytic proliferation and accumulation of the prion protein PrPSc, which can form amyloid plaques.CD230. also known as the prion protein (PrP) exists in two alternate forms; a normal cellular form (PrPc) and a disease-associated form (PrPSc).The normal and pathological forms of the prion protein have identical amino acid sequences and differ only in their folded tertiary structure and biochemical properties.MCA2460 was raised against a synthetic peptide (146-R154R171-182 ) of the ovine PrP peptide and specifically recognises the R151-R159sequence. |
| 产品详情 | | |
| Target Species | Sheep |
| Product Form | Purified IgG - liquid |
| Preparation | Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant |
| Buffer Solution | Phosphate buffered saline |
| Immunogen | Synthetic peptide 146-R154R171-182 of ovine PrP. |
| Approx. Protein Concentrations | IgG concentration 1.0 mg/ml |
| Preservative Stabilisers | 0.09%Sodium Azide |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. This product is photosensitive and should be protected from light. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| ELISA | √ | 1/50 | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
| 推荐产品 |
| Description | Product Code | Applications | Pack Size |
| Goat anti Mouse IgG (H/L):Alk. Phos. (Multi Species Adsorbed) | STAR117A | E;WB | 0.5mg |
| 文献 |
| 1.Andréoletti, O.et al.(2000) Early accumulation of PrP(Sc) in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie.J Gen Virol. 81 (Pt 12): 3115-26.2.Andréoletti, O.et al.(2002) Phenotyping of protein-prion (PrPsc)-accumulating cells in lymphoid and neural tissues of naturally scrapie-affected sheep by double-labeling immunohistochemistry.J Histochem Cytochem. 50 (10): 1357-70.3.Ortiz-Pelaez, A.et al.(2015) Allelic variants at codon 146 in the PRNP gene show significant differences in the risk for natural scrapie in Cypriot goats.Epidemiol Infect. 143 (6): 1304-10.4.Simmons, M.M.et al.(2015) Phenotype shift from atypical scrapie to CH1641 following experimental transmission in sheep.PLoS One. 10 (2): e0117063. |
技术参数 产品应用 ELISA; IHC(P)
产品类型 单克隆抗体
推荐用于 ELISA; IHC(P)
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