Human anti AKT1 antibody, clone AbD30769
货号：HCA308
规格：0.1 mg
价格：2023
产品类型：抗体和染料
品牌：Bio-Rad
抗原：AKT1
物种：其它
宿主：人
抗体亚型：其它
克隆号：AbD30769
荧光染料：其它
| 产品介绍 | | |
| Human anti AKT1 antibody, clone AbD30769recognizes AKT1, also known as RAC-alpha serine/threonine-protein kinase, protein kinase B alpha or Proto-oncogene c-Akt.It belongs to the AGC kinase family (Brown and Banerji 2017). AKT activity is regulated downstream of receptor tyrosine kinases (RTKs) (Frankeet al.1995, Brown and Banerji 2017). Its substrates have a consensus phosphorylation motif: R-X-R-X-X-S/T-B (X is any amino acid and B denotes a preference for bulky hydrophobic residues) (Brown and Banerji 2017). A number of AKT substrates have been described including BAD (BCL2 associated agonist of cell death), FOXO (Forkhead Box), MDM2 (MDM2 oncogene), TSC2 (tuberous sclerosis 2), PRAS40 (proline rich Akt substrate), CDKN (cyclin-dependent kinase inhibitor) and GSK3β (glycogen synthase kinase beta) (Manning and Cantley 2007).AKT is frequently activated in cancer (Manning and Toker 2017). In breast cancer, AKT isoforms play different roles during breast cancer progression (Riggioet al.2017). |
| 产品详情 | | |
| Target Species | Human |
| Product Form | A bivalent human recombinant Fab selected from the HuCAL® phage display library, expressed in E. coli. This Fab fragment is dimerized via an inactive variant of the bacterial alkaline phosphatase (BAP) fusion protein. The antibody is tagged with DYKDDDDK and His (HHHHHH) tags. |
| Preparation | Prepared by affinity chromatography |
| Buffer Solution | Phosphate buffered saline |
| Preservative Stabilisers | 0.01% Thiomersal |
| Immunogen | Recombinant Human AKT1-GST fusion protein |
| Approx. Protein ConcePurityntrations | Antibody concentration 1.0 mg/ml |
| Acknowledgements | This product and/or its use is covered by claims of U.S. patents, and/or pending U.S. and non-U.S. patent applications owned by or under license to Bio-Rad Laboratories, Inc. See bio-rad.com/en-us/trademarks for details.His-tag is a registered trademark of EMD Biosciences. |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Store at -20℃ only.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| ELISA | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
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技术参数 产品应用 elisa；wb
产品类型 单克隆抗体
推荐用于 elisa；wb
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