Rabbit anti RelB (pSer573) antibody
货号：AHP2675
规格：50 µl
价格：3570
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原：RelB (pSer573)
物种：其它
宿主：兔
抗体亚型：IgG
荧光染料：Purified
| 产品介绍 | | |
| Rabbit anti RelB (pSer573) antibodyrecognizes the transcription factor RelB, also known as I-Rel, when phosphorylated at serine 573. RelB is encoded by the v-rel avian reticuloendotheliosis viral oncogene homolog B gene and is a critical component of the NF-kappa-B pathway.Upon cleavage of the NF-kappa-B p105 and p100 subunits into the NF-kappa-B p50 and p52 subunits, RelB forms RelB-p50 and RelB-p52 heterodimers. These dimers act as activators of transcription by binding to kappaB sites present on DNA (Oeckinghaus and Ghosh 2009). RelB-p50 and RelB-p52 binding induces the expression of genes mediating immune responses, inflammation and apoptosis (Jing and Lee 2014).NF-kappa-B pathway has been implicated in a variety of disease states including autoimmunity and cancer. As the NF-kappa-B pathway has been demonstrated to be constitutively active in a large group of tumors and therefore developing NF-kappa-B inhibitors has emerged as a new cancer therapy approach (Chaturverdiet al. 2011,Baud and Karinet al. 2009). RelB is phosphorylated at serine 573 leading to degradation (Marienfeld et al. 2001) |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG - liquid |
| Antiserum Preparation | Antiserum to RelB (pSer573) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. |
| Buffer Solution | Phosphate buffered saline |
| Preservative Stabilisers | 0.02% Sodium Azide50% Glycerol |
| Immunogen | Phospho specific-peptide corresponding to residues surrounding serine 573 of human RelB |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Store at -20℃Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Western Blotting | √ | 1/500 | 1/2000 |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
| 二抗 |
| Description | Product Code | Applications | Pack Size |
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C,E,WB | 1mg |
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E,WB | 1mg |
| 文献 |
| 1.Oeckinghaus, A. & Ghosh, S. (2009) The NF-kappaB family of transcription factors and its regulation.Cold Spring Harb Perspect Biol. 1 (4): a000034.2.Jing, H. & Lee, S. (2014) NF-κB in cellular senescence and cancer treatment.Mol Cells. 37 (3): 189-95.3.Chaturvedi, M.M.et al.(2011) NF-κB addiction and its role in cancer: 'one size does not fit all'.Oncogene. 30 (14): 1615-30.4.Baud, V. & Karin, M. (2009) Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls.Nat Rev Drug Discov. 8 (1): 33-40.5.Marienfeld, R.et al.(2001) Signal-specific and phosphorylation-dependent RelB degradation: a potential mechanism of NF-kappaB control.Oncogene. 20 (56): 8142-7. |
技术参数 产品应用 wb
产品类型 Polyclonal Antibody
推荐用于 wb
©
Bio-Rad伯乐代理官网-伯乐抗体-伯乐层析Aminex色谱柱是专业的授权总代理区域代理经销平台。
© 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
© 本文地址：
https://biorod.cn/thread-34550.htm
QQ:1749072012