Rabbit anti BRCA1 (pSer1423) antibody
货号：AHP2560
规格：50 µl
价格：3570
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原：BRCA1 (pSer1423)
物种：其它
宿主：兔
抗体亚型：IgG
荧光染料：Alexa Fluor 488
| 产品介绍 | | |
| Rabbit anti BRCA1 (pSer1423) antibodyrecognizes breast cancer type 1 susceptibility protein encoded by BRCA1, also known as RING finger protein 53, when phosphorylated at serine 1423. Breast cancer susceptibility genes BRCA1 and BRCA2 are associated with hereditary breast and ovarian cancers. BRCA1 is a tumor suppressor gene encoding an E3 ubiquitin protein ligase that plays a major role in DNA damage repair (Royet al.2011).BRCA1 is also involved in the regulation of multiple processes including transcription and cell cycle progression. BRCA1 is reported to be phosphorylated by ATM and ATR at serine 1423 in response to DNA damage (Tibbettset al.2000). |
| 产品详情 | | |
| Target Species | Human |
| Product Form | Purified IgG - liquid |
| Antiserum Preparation | Antiserum to BRCA1 (pSer1423) was raised by repeated immunization of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. |
| Buffer Solution | Phosphate buffered saline |
| Preservative Stabilisers | 0.02% Sodium Azide50% Glycerol |
| Immunogen | Phospho specific-peptide corresponding to residues surrounding serine 1423 of human BRCA1 |
| Regulatory | For research purposes only |
| Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| Store at -20℃Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. |
| 应用 | | |
| Application Name | Verified | Min Dilution | Max Dilution |
| Western Blotting | √ | 1/500 | 1/2000 |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this antibody has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the antibody for use in their own system using appropriate negative/positive controls. |
| 二抗 |
| Description | Product Code | Applications | Pack Size |
| Goat anti Rabbit IgG (Fc):Biotin | STAR121B | E,WB | 1mg |
| Goat anti Rabbit IgG (H/L):HRP | STAR124P | C,E,WB | 1mg |
技术参数 产品应用 wb
产品类型 Polyclonal Antibody
推荐用于 wb
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