产品介绍 |
| Rabbit anti STAT5A antibodyrecognizes signal transducer and activator of transcription 5A (STAT5A), a member of the STAT protein family. STAT5A plays an important role in cell growth, survival, differentiation and transformation by transducing signals from cytokine receptors to the nucleus.STAT5A is tyrosine phosphorylated by members of the Janus kinase (JAK) family in response to cytokines and growth factor stimulation. Phosphorylation results in STAT activation and the formation of STAT5 homo- and STAT5/STAT3 heterodimers. STAT dimers translocate from the cytoplasm to the nucleus where they act as transcription factors. Deregulated JAK/STAT signaling has been implicated in a variety of cancers, and STATs can regulate the tumor microenvironment to trigger a shift from cancer inhibition to promotion. |
产品详情 |
Target Species | Mouse |
Species Cross-Reactivity | Target Species Cross Reactivity |
| Human √ |
| Rat √ |
| N.B. Antibody reactivity and working conditions may vary between species. |
Product Form | Purified IgG - liquid |
Preparation | Purified IgG prepared by affinity chromatography |
AntiserumPreparation | Antiserum to STAT5A was raised by repeated immunisation of rabbits with highly purified antigen |
Buffer Solution | Phosphate buffered saline |
Preservative Stabilisers | 0.1% Sodium Azide (NaN3)0.2% Gelatin |
Immunogen | Peptide mapping to the carboxy terminus of mouse STAT5A |
Approx. Protein Concentrations | IgG concentration 0.2 mg/mll |
Regulatory | For research purposes only |
Guarantee | 12 months from date of despatch |
存储条件 |
| Store at +4℃. DO NOT FREEZE.This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use. |
应用 |
Application Name | Verified | Min Dilution | Max Dilution |
Western Blotting | √ | 1/200 | |
This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.- Western Blotting
- Rabbit anti STAT5A recognizes a band of approximately 91 kDa when run under reducing conditions
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