Goat anti Human PI-3 kinase p110 subunit alpha antibody
货号：AHP1898
规格：0.1 mg
价格：5083
产品类型：免疫组化一抗
品牌：Bio-Rad
抗原：PI-3 kinase p110 subunit alpha
物种：人
宿主：山羊
抗体亚型：IgG
荧光染料：Purified
| 产品介绍 | | |
| Goat anti Human PI-3 kinase p110 subunit alpha antibodyrecognizes human PI3-kinase p110 subunit alpha (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha), otherwise known as PIK3CA, a member of the PI3/PI4-kinase family of lipid kinases, implicated in the regulation of signal transduction during cell growth.PI3-kinase is a heterodimer consisting of a p85 regulatory subunit and a p110 catalytic subunit, which itself is divided into isoforms p110alpha, p110beta, p110delta and p110gamma. Mutations in the PIK3CA gene are associated with breast, ovarian and colorectal cancers (CRC).http://www.omim.org/entry/114500 Colorectal cancer is a heterogeneous disease that is common in both men and women. characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum (Vehloet al.2005). |
| 产品详情 | | |
Target Species | Human |
| Species Cross-Reactivity | Target Species | Cross Reactivity |
| Mouse | Expected from Sequence |
| Rat | Expected from Sequence |
| Dog | Expected from Sequence |
| Bovine | Expected from Sequence |
| N.B. Antibody reactivity and working conditions may vary between species. |
Product Form | Purified IgG - liquid |
Antiserum Preparation | Antiserum to human p110alpha was raised by repeated immunisation of goats with highly purified antigen.Purified IgG was prepared from whole serum by affinity chromatography. |
Buffer Solution | TRIS buffered saline |
Preservative Stabilisers | 0.02% Sodium Azide (NaN3)0.5% Bovine Serum Albumin |
Immunogen | Synthetic peptide C-HQWLKDKNKGEIYD from the internal region of human PI3-kinase p110 subunit alpha (NP_006209.2). |
| Approx. Protein Concentrations | IgG concentration 0.5 mg/ml |
Regulatory | For research purposes only |
Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
Application Name | Verified | Min Dilution | Max Dilution |
| Immunohistology - Paraffin1 | √ | 2.0 | 3ug/ml |
| ELISA | √ | 1/128000 | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.Histology Positive Control TissueHuman cerebral cortex |
| 数据 |
| Paraffin embedded human brain (cerebellar cortex) stained with Goat anti human p110alpha (AHP1898)。 |
技术参数 产品应用 E;P
产品类型 Polyclonal Antibody
推荐用于 E;P
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