| 产品介绍 | | |
| Mouse anti Human Glial Fibrillary Acidic Protein antibody, clone GF-05recognizes humanm glial fibrillary acidic protein (GFAP). GFAP is a 432 amino acid intermediate filament protein. Mouse anti Human Glial Fibrillary Acidic Protein antibody, clone GF-05 recognisez ~38-45 kDa neurofilaments in immunoblots. Mouse anti Human Glial Fibrillary Acidic Protein antibody, clone GF-05 is also reactive in ELISA with antigen coating at 5 μg/ml and may react with GFAP from other species.Mutations in the GFAP gene may result in presentation of Alexander disease (ALXDRD), a rare neurological condition affecting infants and characterized by myelination failure leading to early death (Brenneret al.2001) |
| 产品详情 | | |
Target Species | Human |
Product Form | Purified IgG - liquid |
Preparation | Purified IgG prepared by affinity chromatography on Protein G |
Buffer Solution | Phosphate buffered saline |
Preservative Stabilisers | <0.1% Sodium Azide (NaN3) |
Approx. Protein Concentrations | IgG concentration 1.0 mg/ml |
Immunogen | Native GFAP purified from human brain. |
Regulatory | For research purposes only |
Guarantee | 12 months from date of despatch |
| 存储条件 | | |
| This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended. |
| 应用 | | |
Application Name | Verified | Min Dilution | Max Dilution |
ELISA | √ | | |
Western Blotting | √ | | |
| This product has been reported to work in the following applications. This information is derived from testing within our laboratories, peer-reviewed publications or personal communications from the originators. Please refer to references indicated for further information. For general protocol recommendations, please visit theantibody protocolspage.Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls. |
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| 文献 |
| 1. Burbaeva, G.Sh.et al. (2007) Systemic neurochemical alterations in schizophrenic brain: glutamate metabolism in focus.Neurochem Res. 32: 1434-44.2. Gil-Perotin, S.et al.(2009) Ultrastructure of the subventricular zone inMacaca fascicularisand evidence of a mouse-like migratory stream.J Comp Neurol. 514: 533-54.3. Wei, P.et al.(2013) Serum GFAP autoantibody as an ELISA-detectable glioma marker.Tumour Biol. 34 (4): 2283-92.4. Garbayo, E.et al.(2016) Brain delivery of microencapsulated GDNF induces functional and structural recovery in parkinsonian monkeys.Biomaterials. 110: 11-23.5. Martinez-Valbuena, M.et al.(2019) Amylin as a potential link between type 2 diabetes and alzheimer disease.Ann Neurol. 86 (4): 539-51.6. Carmona-Abellan, M.et al.(2021) Microglia is associated with p-Tau aggregates in the olfactory bulb of patients with neurodegenerative diseases.Neurol Sci. 42 (4): 1473-82. |
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