Recombinant Human GDF-3
货号：120-22-100,120-22-1000,120-22-20,120-22-250,120-22-5,120-22-500
规格：100ug,1mg,20ug,250ug,5ug,500ug
价格：9171,36743,1568,16052,643,23843
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia that characterizes Type 2 diabetes. Recombinant Human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains.来源:E.coli别名:Growth/Differentiation Factor-3, Vgr-2, UNQ2222/PRO248氨基酸序列:AAIPVPKLSC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGECPFS LTISLNSSNY AFMQALMHAV DPEIPQAVCI PTKLSPISML YQDNNDNVIL RHYEDMVVDE CGCG纯度:≥98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. TheED50for this effect is 100-150 ng/ml.Calculated Molecular Weight:26 kDaAccession Number:Q9NR23Gene ID:9573交叉反应:Frog,Mouse |
product.subtitle.recentcitations |
第一作者 | Levine, A J |
标题 | GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses.Levine, A J |
文献引用 | Developmental Biology; 325(1) pg43-8 |
PubMed Id | 18823971 |
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