CD11b Polyclonal Antibody

货号：PA5-79533

规格：100 µg

价格：2746

产品类型：流式抗体

品牌：Thermo Fisher

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG3

荧光染料：其它

类型:	单抗	同型对照：
浓度：	500 µg/mL	用法：	0.1-0.5 µg/mL (WB)；0.5-1 µg/mL (IHC (P))；0.5-1 µg/mL(IHC (F))；0.5-1 µg/mL (ICC/IF)；1-3 µg/1x10^6 cells (Flow)

产品详细信息Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.An Antigen retrieval buffer of EDTA at pH 8.0 was used to immerse slides during the antigen retrieval process.靶标信息CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). CD11b is expressed on the surface of monocytes/macrophages, granulocytes, activated lymphocytes, a subset of NK cells, a subset of dendritic cells, and microglia in the brain. CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X -these adhesions are critical for cell-cell and cell-matrix interactions. CD11b is expressed on 8% of spleen cells, 44% of bone marrow cells, and less than 1% of thymocytes, and is commonly used as a microglial marker in nervous tissue. The expression of CD11b increases during monocyte maturation and expression levels vary on tissue macrophages. Further, peritoneal macrophages are reported to express higher levels of CD11b than splenic macrophages. Diseases associated with CD11b dysfunction include systemic lupus erythematosus 6 and ITGAM-related susceptibility to systemic lupus erythematosus.

数据

CD11b Antibody (PA5-79533) in IHC (P)Immunohistochemistry analysis of CD11b on paraffin-embedded mouse spleen tissue. Sample was incubated with CD11b polyclonal antibody (Product# PA5-79533).

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