Applications

FA

Synonyms:

AHPN, CD437, O-Desmethyl Adapalene, 6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic Acid

Formulation:

Crystalline solid

Chemical Name:

6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid

Molecular Formula:

C₂₇H₂₆O₃

Molecular Weight:

398.5

CAS Number

125316-60-1

Purity:

≥95%

Storage Conditions:

Product should be kept at -20°C.

References:

Sun, S. Y., Yue, P., & Lotan, R. (2000). Implication of multiple mechanisms in apoptosis induced by the synthetic retinoid CD437 in human prostate carcinoma cells.Oncogene,19(39), 4513-4522.

Li, Y., Lin, B., Agadir, A., Liu, R., Dawson, M. I., Reed, J. C., ... & Zhang, X. K. (1998). Molecular determinants of AHPN (CD437)-induced growth arrest and apoptosis in human lung cancer cell lines.Molecular and cellular biology,18(8), 4719-4731.

Wang, W., Yang, J., Liu, H., Lu, D., Chen, X., Zenonos, Z., ... & Liu, P. (2011). Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.Proceedings of the National Academy of Sciences,108(45), 18283-18288.