CH 223191

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CH 223191

货号:3012272-50,3012272-10

规格:50 mg,10mg

价格:6600,1595

产品类型:小分子化合物

品牌:Biogems

CH 223191 is a specific and potent antagonist to the aryl hydrocarbon receptor (AhR), a ligand-dependent transcription factor that is involved in drug and xenobiotic metabolism. Unlike other AhR antagonists, it does not react with the estrogen receptor and is observed to effect AhR-dependent reporter gene expression in human, mouse, rat, and guinea pig cell lines. CH223191 is reported to exhibit AHR-independent pro-proliferative properties

Additional Information

Applications

FA

Synonyms:

AhR Antagonist, CH223191, AGN-PC-0KP4EW, Aryl hydrocarbon receptor antagonist

Formulation:

Crystalline solid

Chemical Name:

2-methyl-N-[2-methyl-4-[(2-methylphenyl)diazenyl]phenyl]pyrazole-3-carboxamide

Molecular Formula:

C19H19N5O

Molecular Weight:

333.4

CAS Number

301326-22-7

Purity:

≥95%

Storage Conditions:

Product should be kept at -20°C.

References:

Zhao, B., DeGroot, D. E., Hayashi, A., He, G., & Denison, M. S. (2010). CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor.Toxicological Sciences,117(2), 393-403.

Choi, E. Y., Lee, H., Dingle, R. C., Kim, K. B., & Swanson, H. I. (2012). Development of novel CH223191-based antagonists of the aryl hydrocarbon receptor.Molecular pharmacology,81(1), 3-11.

Yoshida, T., Katsuya, K., Oka, T., Koizumi, S. I., Wakita, D., Kitamura, H., & Nishimura, T. (2012). Effects of AhR ligands on the production of immunoglobulins in purified mouse B cells.Biomedical research,33(2), 67-74.

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