Applications

FA

Synonyms:

Chir99021, CHEMBL412142, GSK-3 Inhibitor XVI, AGN-PC-0MWAEX

Formulation:

Crystalline solid

Chemical Name:

6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile

Molecular Formula:

C₂₂H₁₈Cl₂N₈

Molecular Weight:

465.3

CAS Number

252917-06-9

Purity:

≥95%

Storage Conditions:

Product should be kept at -20°C.

References:

Li, W., Wei, W., Zhu, S., Zhu, J., Shi, Y., Lin, T., ... & Ding, S. (2009). Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.Cell stem cell,4(1), 16-19.

Ye, S., Tan, L., Yang, R., Fang, B., Qu, S., Schulze, E. N., ... & Li, P. (2012). Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains.PloS one,7(4), e35892.

Wu, Y., Ai, Z., Yao, K., Cao, L., Du, J., Shi, X., ... & Zhang, Y. (2013). CHIR99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding RNA expression.Experimental cell research,319(17), 2684-2699.