Applications

FA

Synonyms:

BIRB796

Formulation:

Crystalline solid

Chemical Name:

1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea

Molecular Formula:

C₃₁H₃₇N₅O₃

Molecular Weight:

CAS Number

285983-48-4

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Pargellis, C., Tong, L., Churchill, L., Cirillo, P. F., Gilmore, T., Graham, A. G., ... & Regan, J. (2002). Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site.Nature Structural & Molecular Biology,9(4), 268-272.

Regan, J., Pargellis, C. A., Cirillo, P. F., Gilmore, T., Hickey, E. R., Peet, G. W., ... & Moss, N. (2003). The kinetics of binding to p38MAP kinase by analogues of BIRB 796.Bioorganic & medicinal chemistry letters,13(18), 3101-3104.

Kumar, S., Boehm, J., & Lee, J. C. (2003). p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases.Nature reviews Drug discovery,2(9), 717-726.